Depends on your cat. My cat, I kind of cradle the back of her head, behind her ears in one hand, (think scruffing but not scruffing bc that’s not nice). With my dominant hand (the hand to the front of her, I come at her from the side), I lift her chin, open her mouth with a finger, and with my index finger push the pill to the back of her tongue.

She’s had to take a lot of pills in her life so we have it down pat. But it’s mostly about being firm but not scaring them.